Description

1-(3-Chloropyridin-4-Yl)-2,2,2-Trifluoroethanone is a high-value trifluoromethyl ketone building block featuring a chloropyridine scaffold, making it a critical intermediate for advanced synthesis. Its core value lies in enabling the introduction of the trifluoroacetyl pharmacophore, which is essential for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Material Science: Serves as a precursor for advanced functional materials, including liquid crystals and organic semiconductors.
• Chemical Synthesis: Acts as a versatile electrophile in nucleophilic addition reactions and as a precursor for heterocyclic compounds via cyclization reactions.
• Fluorine Chemistry: An important reagent for introducing fluorine-containing motifs into complex organic molecules, a crucial strategy in modern medicinal chemistry.

Basic Information

Item	Detail
Product Name	1-(3-Chloropyridin-4-Yl)-2,2,2-Trifluoroethanone
CAS No.	1060802-13-2
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	4-Chloro-3-(2,2,2-trifluoroacetyl)pyridine; 3-Chloro-4-(2,2,2-trifluoroacetyl)pyridine; 1-(3-Chloro-4-pyridinyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(3-chloropyridin-4-yl)ethanone; 3-Chloro-4-pyridyl trifluoromethyl ketone; 4-Chloro-3-pyridyl trifluoromethyl ketone; 1-(3-Chloro-4-pyridyl)-2,2,2-trifluoroethanone
EINECS	Contact for details

Quality Control

Our 1-(3-Chloropyridin-4-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. This material should be stored separately from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.