Description

5-Trifluoromethyl-Pyridine-3-Sulfonyl Chloride is a high-value, reactive organosulfur building block essential for advanced synthetic chemistry. Its core value lies in its ability to act as a versatile sulfonylation reagent, facilitating the introduction of the sulfonyl group into complex molecular architectures. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethylpyridine moiety often enhances biological activity and metabolic stability.
• Functional Material Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and electronic materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling proteins, modifying peptides, or creating activity-based probes for enzyme studies.
• Sulfonamide Library Synthesis: A crucial reagent in high-throughput and combinatorial chemistry for generating diverse sulfonamide-based compound libraries for screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific sulfonyl chloride derivatives.

Basic Information

Product Name	5-Trifluoromethyl-Pyridine-3-Sulfonyl Chloride
CAS No.	1060802-03-0
Molecular Formula	C7H3ClF3NO2S
Molecular Weight	245.61 g/mol
Synonyms	3-Pyridinesulfonyl chloride, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)pyridine-3-sulfonyl chloride; 5-Trifluoromethyl-3-pyridinesulfonyl chloride; 3-Chlorosulfonyl-5-(trifluoromethyl)pyridine; 1060802-03-0; 5-Trifluoromethylpyridine-3-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethyl-Pyridine-3-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and reactive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.