Description

2,2,2-Trifluoro-1-(3-Methylpyridin-2-Yl)Ethanone is a high-purity trifluoromethyl ketone derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl group, which is essential for modulating the biological activity and metabolic stability of target molecules. This compound is primarily needed by pharmaceutical R&D and agrochemical manufacturers for the development of novel active ingredients, as well as by specialty chemical companies engaged in fluorination chemistry.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and environmental stability.
• Fluorinated Material Precursor: Serves as a starting material for synthesizing more complex fluorinated compounds used in liquid crystals, organic electronics, and specialty polymers.
• Chemical Biology Probe Development: Employed in medicinal chemistry to create enzyme inhibitors or receptor ligands, leveraging the ketone moiety for further derivatization.
• Catalysis & Ligand Synthesis: Potential use in the preparation of novel chiral ligands or organocatalysts for asymmetric synthesis.

Basic Information

Product Name	2,2,2-Trifluoro-1-(3-Methylpyridin-2-Yl)Ethanone
CAS No.	1060801-54-8
Molecular Formula	C8H6F3NO
Molecular Weight	189.14 g/mol
Synonyms	1-(3-Methyl-2-pyridinyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(3-methyl-2-pyridinyl)ethanone; 3-Methyl-2-pyridinyl trifluoromethyl ketone; 2-Acetyl-3-methylpyridine trifluoromethyl ketone; 2,2,2-Trifluoro-1-(3-methylpyridin-2-yl)ethan-1-one; TFMPK derivative; 1060801-54-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(3-Methylpyridin-2-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.