Description

1-(2-Chloropyridin-3-Yl)-2,2,2-Trifluoroethanone is a high-value trifluoromethyl ketone building block, essential for advanced organic synthesis. Its unique structure, featuring both a chloropyridine moiety and a reactive trifluoroacetyl group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine and trifluoromethyl groups.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry: A valuable reagent for introducing the trifluoromethyl ketone functionality into target molecules, a common motif in medicinal chemistry.

Basic Information

Product Name	1-(2-Chloropyridin-3-Yl)-2,2,2-Trifluoroethanone
CAS No.	1057657-62-1
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	2-Chloro-3-(trifluoroacetyl)pyridine; 3-Acetyl-2-chloropyridine, 2,2,2-trifluoro-; 2-Chloro-3-pyridyl trifluoromethyl ketone; 1-(2-Chloro-3-pyridinyl)-2,2,2-trifluoroethanone; 2-Chloro-3-trifluoroacetylpyridine; 3-(Trifluoroacetyl)-2-chloropyridine; 2-Chloropyridin-3-yl trifluoromethyl ketone; 1057657-62-1
EINECS	Contact for details

Quality Control

Our 1-(2-Chloropyridin-3-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.