Description

1-Boc-3-Fluoro-3-Formylpyrrolidine is a high-value, multi-functional building block featuring a protected amine (Boc), a fluorine atom, and an aldehyde group on a pyrrolidine scaffold. This unique combination of functional groups makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily used by medicinal chemists and process development scientists in the life sciences industry for constructing novel drug candidates, especially those targeting the central nervous system and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in high-throughput screening and combinatorial chemistry to create diverse compound libraries for drug discovery programs.
• Fluorinated Compound Synthesis: Serves as a precursor for introducing the fluorine atom, a common bioisostere, to improve metabolic stability, bioavailability, and binding affinity of drug molecules.
• Peptidomimetic Development: The pyrrolidine core and aldehyde functionality make it valuable for designing and synthesizing peptidomimetics and constrained peptides.
• Agrochemical Research: Potential use as an intermediate in the synthesis of advanced, fluorinated agrochemicals and pesticides.
• Material Science Precursor: Can be utilized in the synthesis of specialized ligands, catalysts, or functionalized polymers for advanced material applications.

Basic Information

Product Name	1-Boc-3-Fluoro-3-Formylpyrrolidine
CAS No.	1057322-52-7
Molecular Formula	C10H16FNO3
Molecular Weight	217.24 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-fluoro-3-formylpyrrolidine; tert-Butyl 3-fluoro-3-formylpyrrolidine-1-carboxylate; 3-Fluoro-3-formylpyrrolidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-fluoro-3-pyrrolidinecarboxaldehyde; N-Boc-3-fluoro-3-formylpyrrolidine; 3-Fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carbaldehyde; 1057322-52-7; Boc-3-Fluoro-3-formylpyrrolidine
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Fluoro-3-Formylpyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical R&D, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.