Description

Cyt387 2H2So4 Salt is a high-purity, non-hygroscopic salt form of the investigational Janus kinase (JAK) inhibitor Momelotinib. This specific salt form is critical for enhancing the compound's stability, solubility, and manufacturability for advanced pharmaceutical development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of targeted therapies for myelofibrosis and other hematologic conditions. The compound is supplied under stringent quality controls to ensure batch-to-batch consistency for preclinical and clinical research applications.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and analytical method development in drug manufacturing.
• Preclinical Research: Used in in vitro and in vivo studies to investigate JAK1/JAK2 inhibition pathways.
• Formulation Development: A key intermediate in the development of stable and bioavailable dosage forms, such as tablets or capsules.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for active pharmaceutical ingredient (API) production.
• Clinical Trial Material: Supplied as a high-grade ingredient for the GMP-compliant production of clinical trial supplies.

Basic Information

Product Name	Cyt387 2H2So4 Salt
CAS No.	1056636-06-6
Molecular Formula	C₂₃H₃₂N₆O₄ • 2H₂SO₄
Molecular Weight	648.73 g/mol
Synonyms	Momelotinib Disulfate Salt; GS-0387 Disulfate; CYT387 Disulfate; 2-Pyrimidinamine, N-(cyanomethyl)-4-[2-[(4-morpholinyl)methyl]-1H-benzimidazol-1-yl]-, sulfate (1:2); 9H-Purine-6-carboxamide, 2-[2-(1H-imidazol-1-yl)ethyl]-1,9-dihydro-9-hydroxy-; Momelotinib bis(sulfate)
EINECS	Contact for details

Quality Control

Every batch of Cyt387 2H2So4 Salt is manufactured and tested to meet exacting standards for pharmaceutical research. Our rigorous quality testing includes identity confirmation, purity assay, and impurity profiling to ensure compliance with internal specifications suitable for preclinical and development use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support development needs with documentation traceability and can align with GMP guidelines for advanced phase applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.