Description

10α-Hydroxy-Nalfurafine is a potent and selective κ-opioid receptor (KOR) agonist, representing a significant advancement in the study of opioid pharmacology. This compound is of critical importance for pharmaceutical research and development, particularly in the investigation of novel analgesic pathways and treatments for pruritus (chronic itching). It is primarily needed by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in neuroscience, pain management, and drug discovery programs.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in drug manufacturing and regulatory submissions.
• Preclinical Research: Used in vitro and in vivo studies to investigate the pharmacology, efficacy, and safety profile of κ-opioid receptor agonists.
• Mechanistic Studies: A key tool for elucidating the role of the KOR pathway in pain modulation, neuropsychiatric disorders, and pruritus.
• Drug Discovery & Development: Acts as a lead compound or pharmacophore model for the design and synthesis of new therapeutic agents targeting opioid receptors.
• Biochemical Assays: Utilized in receptor binding assays and functional tests to screen and characterize new chemical entities.

Basic Information

Product Name	10α-Hydroxy-Nalfurafine
CAS No.	1054312-75-2
Molecular Formula	C₂₈H₃₅N₃O₅
Molecular Weight	481.60 g/mol
Synonyms	10α-Hydroxy Nalfurafine; 10α-Hydroxy-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinan; TRK-820 metabolite (10α-hydroxy); 10α-Hydroxy TRK-820; 10α-OH-Nalfurafine
EINECS	Contact for details

Quality Control

Our 10α-Hydroxy-Nalfurafine is manufactured under strict quality management systems to ensure the highest standards of purity and consistency. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP guidelines where applicable to support our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity	≤0.5%
Total Impurities	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.