Description

2-Hydroxy Imipramine 2,3,4-Triacetate-β-D-Glucopyranuronic Acid Methyl Ester CAS NO 1053632-53-3 is a sophisticated glucuronide conjugate derivative of the tricyclic antidepressant imipramine, designed for advanced pharmaceutical research and development. This compound is critical for studying the metabolic pathways, pharmacokinetics, and detoxification mechanisms of imipramine and related therapeutics. It serves as a vital reference standard and synthetic intermediate for researchers and manufacturers in the pharmaceutical, analytical chemistry, and life science sectors.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the quantitative and qualitative analysis of imipramine metabolites in bioanalytical studies (e.g., HPLC, LC-MS).
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Essential for investigating Phase II metabolism, specifically glucuronidation, to understand drug clearance, bioavailability, and potential drug-drug interactions.
• Metabolite Synthesis & Characterization: Acts as a key synthetic intermediate or final product for the preparation and structural elucidation of imipramine's hydroxylated and conjugated metabolites.
• Toxicological Studies: Employed in research to assess the safety profile, toxicity, and excretion pathways of imipramine and its derivatives.
• Biochemical Assay Development: Utilized in developing and validating in-vitro assays for enzyme activity (e.g., UGT enzymes) involved in drug conjugation.
• Academic & Institutional Research: Supports fundamental neuroscience and pharmacology research in universities and government laboratories.

Basic Information

Product Name	2-Hydroxy Imipramine 2,3,4-Triacetate-β-D-Glucopyranuronic Acid Methyl Ester
CAS No.	1053632-53-3
Molecular Formula	C36H43N3O12
Molecular Weight	709.75 g/mol
Synonyms	2-Hydroxyimipramine 2,3,4-tri-O-acetyl-β-D-glucopyranuronate methyl ester; Methyl (2R,3S,4S,5R,6S)-3,4,5-triacetoxy-6-((5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-2-yl)oxy)tetrahydro-2H-pyran-2-carboxylate; Imipramine metabolite glucuronide derivative; 2-OH-Imipramine triacetyl glucuronide methyl ester; Imipramine glucuronide conjugate (acetylated, methylated); 2-Hydroxy Desipramine glucuronide analog (acetylated)
EINECS	Contact for details

Quality Control

Our production of 2-Hydroxy Imipramine 2,3,4-Triacetate-β-D-Glucopyranuronic Acid Methyl Ester adheres to stringent quality management protocols. Each batch is characterized and verified using advanced analytical techniques including NMR, HPLC, and MS to ensure structural identity and high chemical purity. We provide comprehensive Certificates of Analysis (COA) detailing purity, impurities, and analytical results. Our quality system supports compliance with research and development standards for pharmaceutical intermediates and reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation. Store in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.