Description

Silodosin-D6 is a deuterium-labeled analog of the selective α-1A adrenergic receptor antagonist Silodosin, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic, metabolic, and bioanalytical studies. It is a critical tool for pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug development and quality control.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application for the precise quantification of Silodosin in biological matrices (plasma, serum, urine) during clinical and preclinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry to track drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Bioanalytical Method Development and Validation: Serves as a critical reference compound to establish and validate robust, sensitive, and specific analytical assays.
• Pharmaceutical Quality Control: Employed in the analysis of drug substances and finished products to ensure potency and purity.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly accurate quantification by correcting for analyte loss during sample preparation and instrument variability.
• Metabolite Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.

Basic Information

Product Name	Silodosin-D6
CAS No.	1051374-52-7
Molecular Formula	C25H26D6F3N3O4
Molecular Weight	505.55 g/mol
Synonyms	Silodosin-d6; 1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide-d6; KMD-3213-d6; (R)-Silodosin-d6; Urief-d6; Deuterated Silodosin; Silodosin Internal Standard; Silodosin-d6 (hexadeuterated)
EINECS	Contact for details

Quality Control

Every batch of Silodosin-D6 is manufactured and tested under strict quality management systems to ensure it meets the exacting standards required for analytical applications. We provide comprehensive Certificates of Analysis (COA) that detail critical parameters including chemical purity, isotopic purity (enrichment), and chromatographic profile. Our quality commitment supports compliance with cGMP and ICH guidelines for reference standards used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Enrichment)	≥ 98.0 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.