Description

3,4-Difluorophenylglyoxal Hydrate is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where the introduction of a reactive glyoxal moiety adjacent to a difluorophenyl ring is critical.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, leveraging the bioactivity of the difluorophenyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced organic materials, including monomers for specialty polymers and liquid crystals.
• Chemical Biology Probes: Utilized to create fluorescent tags or affinity probes for studying biological systems and target engagement.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	3,4-Difluorophenylglyoxal Hydrate
CAS No.	1049753-77-6
Molecular Formula	C8H6F2O3 • xH2O
Molecular Weight	188.13 (Anhydrous basis)
Synonyms	(3,4-Difluorophenyl)glyoxal hydrate; 2-Oxo-2-(3,4-difluorophenyl)acetaldehyde hydrate; 3,4-Difluorobenzoylformaldehyde hydrate; 3,4-Difluorophenyl-α-oxoacetaldehyde hydrate; Glyoxal, (3,4-difluorophenyl)-, hydrate (1:?); 1-(3,4-Difluorophenyl)-1,2-ethanedione hydrate
EINECS	Contact for details

Quality Control

Our 3,4-Difluorophenylglyoxal Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability and consistency for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under a dry inert atmosphere (e.g., nitrogen or argon) for prolonged use and to store at controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.