Description

1-(3-Bromo-5-(Trifluoromethyl)Pyridin-2-Yl)Ethanone is a high-value, multi-functional pyridine derivative and a key building block in advanced organic synthesis. Its molecular structure, featuring both bromo and trifluoromethyl substituents, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form complex biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Item	Details
Product Name	1-(3-Bromo-5-(Trifluoromethyl)Pyridin-2-Yl)Ethanone
CAS No.	1048384-87-7
Molecular Formula	C8H5BrF3NO
Molecular Weight	268.03 g/mol
Synonyms	2-Acetyl-3-bromo-5-(trifluoromethyl)pyridine; 3-Bromo-5-(trifluoromethyl)-2-acetylpyridine; 1-[3-Bromo-5-(trifluoromethyl)-2-pyridinyl]ethanone; Ethanone, 1-[3-bromo-5-(trifluoromethyl)-2-pyridinyl]-; 2-Pyridineacetyl, 3-bromo-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 1-(3-Bromo-5-(Trifluoromethyl)Pyridin-2-Yl)Ethanone is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (HPLC), with higher purity grades available upon request. Certificates of Analysis (COA) detailing all relevant specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.