Description

Gsk-2110183C is a potent and selective small molecule inhibitor primarily used in biochemical and pharmacological research. This compound is valued for its high specificity in modulating key cellular signaling pathways, making it a critical tool for target validation and mechanistic studies. It is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on oncology, immunology, and metabolic disease research.

Application

• Biochemical Research: Used as a selective inhibitor to study specific kinase activity and downstream signaling cascades in vitro.
• Drug Discovery & Target Validation: A key pharmacological tool for validating novel therapeutic targets in preclinical models.
• Cell Biology Studies: Employed to investigate the role of specific pathways in cell proliferation, apoptosis, and differentiation.
• Academic Research: Fundamental reagent for universities and research institutes exploring cellular mechanisms and disease pathology.
• Pharmaceutical Development: Supports lead optimization and compound screening efforts in early-stage drug development programs.
• Biomarker Research: Aids in understanding the relationship between pathway inhibition and potential biomarker expression.

Basic Information

Product Name	Gsk-2110183C
CAS No.	1047644-62-1
Molecular Formula	C₂₀H₂₅N₅O₃
Molecular Weight	383.45 g/mol
Synonyms	GSK2110183C; GSK-2110183; 5-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-3-[(1R)-1-(2-methyl-1,3-thiazol-4-yl)ethyl]-1,3,4-oxadiazol-2(3H)-one; Akt Inhibitor GSK2110183; GSK 2110183; Afuresertib (base); AT13148 (common research alias)
EINECS	Contact for details

Quality Control

Our Gsk-2110183C is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) with batch-specific data is provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.