Description

6-Amino-4-(Trifluoromethyl)Pyridin-3-Ylboronic Acid is a high-value, multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its primary commercial value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who are developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used to construct novel heterocyclic scaffolds for the development of new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science: Employed in the creation of organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors), due to its electron-deficient pyridine core.
• Chemical Biology & Proteomics: Acts as a handle for bioconjugation and the development of molecular probes and inhibitors for studying biological pathways.
• Ligand Synthesis: Serves as a starting material for the preparation of sophisticated ligands used in catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis organizations (CSOs) and CDMOs (Contract Development and Manufacturing Organizations) serving global R&D pipelines.

Basic Information

Product Name	6-Amino-4-(Trifluoromethyl)Pyridin-3-Ylboronic Acid
CAS No.	1045861-32-2
Molecular Formula	C6H6BF3N2O2
Molecular Weight	205.94 g/mol
Synonyms	(6-Amino-4-(trifluoromethyl)pyridin-3-yl)boronic acid; 3-Borono-6-amino-4-(trifluoromethyl)pyridine; 6-Amino-4-trifluoromethyl-3-pyridineboronic acid; 6-Amino-4-(trifluoromethyl)-3-pyridinylboronic acid; Boronic acid, B-[6-amino-4-(trifluoromethyl)-3-pyridinyl]-; 1045861-32-2; 6-Amino-4-(trifluoromethyl)pyridine-3-boronic acid
EINECS	Contact for details

Quality Control

Our 6-Amino-4-(Trifluoromethyl)Pyridin-3-Ylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.