Description

5-Fluoro-2-Methoxypyridine-4-Boronic Acid is a high-value boronic acid derivative and a key building block in modern synthetic chemistry. Its primary importance lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs), advanced intermediates, and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, especially those containing the 5-fluoro-2-methoxypyridine scaffold for oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Serves as a building block for constructing organic electronic materials, ligands for catalysts, and advanced polymers.
• Suzuki-Miyaura Cross-Coupling Reactions: The primary application, enabling carbon-carbon bond formation to create complex, functionalized aromatic and heteroaromatic compounds under mild conditions.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes and bioconjugation reagents for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	5-Fluoro-2-Methoxypyridine-4-Boronic Acid
CAS No.	1043869-98-2
Molecular Formula	C6H7BFNO3
Molecular Weight	170.94 g/mol
Synonyms	(5-Fluoro-2-methoxypyridin-4-yl)boronic acid; 4-Borono-5-fluoro-2-methoxypyridine; 5-Fluoro-2-methoxy-4-pyridineboronic acid; 5-Fluoro-2-methoxypyridine-4-boronic acid pinacol ester (common derivative); 4-Pyridineboronic acid, 5-fluoro-2-methoxy-; 1043869-98-2; 5-Fluoro-2-methoxyisonicotinic acid boronic acid derivative
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methoxypyridine-4-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.