Description

Cl-Amidine CAS NO 1043444-18-3 is a potent and selective covalent inhibitor of protein arginine deiminases (PADs), a class of enzymes implicated in various disease pathways. This high-purity biochemical tool is essential for researchers and pharmaceutical developers investigating novel therapeutic targets in autoimmune disorders, oncology, and neurodegenerative diseases. It is primarily utilized in academic research, drug discovery, and preclinical development within the life sciences sector.

Application

• Biochemical Research: A critical tool compound for studying PAD enzyme activity, structure, and function in vitro.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore model for designing novel PAD-targeted therapeutics.
• Autoimmune Disease Research: Used in models of rheumatoid arthritis, lupus, and multiple sclerosis to elucidate the role of citrullination in disease pathology.
• Oncology Research: Investigated for its potential role in modulating tumor progression and the tumor microenvironment via PAD inhibition.
• Neuroscience Studies: Applied in research on neurodegenerative conditions like Alzheimer's disease where PAD activity may be dysregulated.
• Inhibitor Specificity Profiling: Employed to validate the selectivity of PAD isoforms (PAD1-4) in complex biological assays.

Basic Information

Product Name	Cl-Amidine
CAS No.	1043444-18-3
Molecular Formula	C11H16ClN5O2
Molecular Weight	285.73 g/mol
Synonyms	N-α-Benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide; (2S)-5-(2-Chloroethanimidamido)-2-benzamidopentanoic acid; Cl-Amidine hydrochloride (common salt form); PAD Inhibitor Cl-Amidine; Benzoyl-Cl-Amidine; Protein Arginine Deiminase Inhibitor
EINECS	Contact for details

Quality Control

Our Cl-Amidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to high standards suitable for research and development use, with specifications available to meet the rigorous demands of pharmaceutical and academic laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.