Description

Stat3 Inhibitor Vii is a potent and selective cell-permeable inhibitor of Signal Transducer and Activator of Transcription 3 (STAT3), a key signaling protein implicated in oncogenesis. This compound is critical for researchers investigating STAT3-dependent pathways in cancer, inflammation, and autoimmune diseases. It is an essential tool for pharmaceutical R&D, academic research, and biotechnology companies focused on developing targeted cancer therapies and validating STAT3 as a therapeutic target.

Application

• Biomedical Research: Used as a key pharmacological tool to inhibit STAT3 phosphorylation and dimerization in cell-based assays and signal transduction studies.
• Oncology Research: Critical for studying the role of constitutive STAT3 activation in tumor cell proliferation, survival, angiogenesis, and immune evasion.
• Drug Discovery & Validation: Serves as a reference compound in high-throughput screening (HTS) campaigns and for validating novel STAT3 inhibitors in preclinical models.
• Inflammation & Immunology Studies: Applied to dissect STAT3 signaling in immune cells, including T-cells and macrophages, relevant to autoimmune and chronic inflammatory conditions.
• Functional Genomics: Used in combination with genetic knockdown/knockout techniques to confirm phenotype specificity to STAT3 inhibition.
• Mechanism of Action (MoA) Studies: Employed to elucidate downstream effects and synthetic lethal interactions resulting from STAT3 pathway blockade.

Basic Information

Product Name	Stat3 Inhibitor Vii
CAS No.	1041438-68-9
Molecular Formula	C₂₀H₁₅N₅O₂S
Molecular Weight	389.43 g/mol
Synonyms	STAT3 Inhibitor VII; NSC 74859; S3I-201; 2-Hydroxy-4-[[(4-methylphenyl)sulfonyl]acetyl]amino]benzoic acid; 4-((2-Carboxyphenyl)amino)-4-oxo-2-((4-methylphenyl)sulfonyl)butanoic acid; Stattic analog S3I-201; Calbiochem Stat3 Inhibitor Vii
EINECS	Contact for details

Quality Control

Our Stat3 Inhibitor Vii is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing identity, purity, and potency are available upon request to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.