Description

Mch-1 Antagonist 1 is a potent and selective small-molecule antagonist of the melanin-concentrating hormone receptor 1 (MCHR1), a key target in neuroendocrine and metabolic research. This high-purity compound is essential for advancing studies in obesity, anxiety, depression, and sleep disorders, providing researchers with a reliable tool for in vitro and in vivo pharmacological investigations. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs (Contract Research Organizations) focused on central nervous system (CNS) drug discovery and metabolic disease pathways.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies investigating the role of the MCH system in energy homeostasis and feeding behavior.
• Drug Discovery & Development: Serves as a key chemical probe for high-throughput screening (HTS), lead optimization, and preclinical validation of novel MCHR1 antagonists for metabolic disorders.
• Neuroscience Studies: Applied in behavioral assays to elucidate the function of MCHR1 in mood regulation, anxiety, depression, and sleep-wake cycles.
• Biochemical Assays: Employed in receptor binding studies, functional cellular assays (e.g., cAMP inhibition, calcium flux), and selectivity profiling.
• Academic Research: A critical reagent for university and institutional labs exploring neuropeptide signaling and its implications in disease.
• CRO Services: Supplied to contract research organizations providing integrated drug discovery and preclinical testing services for client projects.

Basic Information

Product Name	Mch-1 Antagonist 1
CAS No.	1039825-68-7
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	MCH-1 Antagonist 1; MCHR1 Antagonist 1; 2-[(3S)-3-(Methylamino)pyrrolidin-1-yl]-4-(5-methyl-1,3,4-oxadiazol-2-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidine; SNAP 7941; SNAP-7941; (S)-SNAP 7941; SNAP7941
EINECS	Contact for details

Quality Control

Our Mch-1 Antagonist 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR and MS confirmation of structure, and determination of chiral purity. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under desiccated conditions. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.