Description

Ipi-926 CAS NO 1037210-93-7 is a potent and selective small molecule inhibitor of the Hedgehog (Hh) signaling pathway, specifically targeting the Smoothened (Smo) receptor. This compound is critical for advanced research in oncology and developmental biology, offering a precise tool for modulating a key pathway involved in cell proliferation and differentiation. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in cancer drug discovery and mechanistic studies of Hh pathway-related diseases.

Application

• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies targeting Hedgehog pathway-dependent cancers, such as basal cell carcinoma and medulloblastoma.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the synthesis and optimization of novel Smoothened receptor antagonists.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro assays to study Hedgehog signaling inhibition and mechanism of action.
• Academic & Biomedical Research: Facilitates fundamental research into the role of the Hedgehog pathway in tissue regeneration, stem cell biology, and developmental disorders.

Basic Information

Item	Details
Product Name	Ipi-926
CAS No.	1037210-93-7
Molecular Formula	C₂₆H₂₈N₄O₃
Molecular Weight	444.53 g/mol
Synonyms	IPI-926; Saridegib; 2-[(3R)-3-[2-(1H-Indol-4-yl)ethyl]-1-methyl-2,5-dioxo-4-imidazolidinyl]-N-[4-(trifluoromethoxy)phenyl]acetamide; UNII-1Q8S6K309V; Hedgehog pathway inhibitor IPI-926; Smoothened antagonist IPI-926; Saridegib (USAN)
EINECS	Contact for details

Quality Control

Our Ipi-926 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.