Description

Yk-4-279 is a potent and selective small molecule inhibitor of the ETV6-NTRK3 oncogenic fusion protein. This compound matters because it represents a targeted research tool for investigating the role of NTRK fusions in cancer cell proliferation and survival, offering a pathway to potential therapeutic strategies. It is primarily needed by researchers and pharmaceutical developers in the fields of oncology, molecular biology, and medicinal chemistry for drug discovery and preclinical studies.

Application

• Oncology Research: Used as a biochemical tool to study the inhibition of the ETV6-NTRK3 fusion kinase and its downstream signaling pathways in cellular and animal models.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for novel TRK inhibitors.
• Mechanistic Studies: Employed to elucidate the biological functions of NTRK gene fusions in various cancer types, including secretory breast carcinoma and congenital fibrosarcoma.
• Preclinical Validation: Utilized in proof-of-concept experiments to validate NTRK fusion proteins as viable therapeutic targets.
• Biochemical Assays: Acts as a specific inhibitor in kinase assay development and biochemical profiling.

Basic Information

Product Name	Yk-4-279
CAS No.	1037184-44-3
Molecular Formula	C₂₀H₁₇N₅O₂
Molecular Weight	359.38 g/mol
Synonyms	YK 4-279; YK4279; (E)-N-(3-((5-(Dimethylamino)-1-naphthalenyl)sulfonyl)phenyl)-3-(4-pyridinyl)-2-propenamide; ETV6-NTRK3 Inhibitor; NTRK Fusion Inhibitor; TRK Inhibitor YK-4-279
EINECS	Contact for details

Quality Control

Our Yk-4-279 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure consistency and reliability for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.