Description

Imidazo[1,2-A]Pyridine, 3-Iodo-7-(Trifluoromethyl)- is a high-value, halogenated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique structure, featuring both iodine and trifluoromethyl substituents, provides versatile handles for further functionalization via cross-coupling reactions and introduces desirable physicochemical properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for targets requiring halogenated or fluorinated scaffolds.
• Agrochemical Research: Used in developing new active ingredients for crop protection, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for catalysts or components in organic light-emitting diodes (OLEDs).
• Chemical Biology: Employed as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies due to its reactive iodine moiety.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Fluorine Chemistry: Acts as a starting material for introducing the pharmacologically beneficial trifluoromethyl group into more complex molecules.

Basic Information

Product Name	Imidazo[1,2-A]Pyridine, 3-Iodo-7-(Trifluoromethyl)-
CAS No.	1036990-96-1
Molecular Formula	C8H4F3IN2
Molecular Weight	312.03 g/mol
Synonyms	3-Iodo-7-(trifluoromethyl)imidazo[1,2-a]pyridine; 7-(Trifluoromethyl)-3-iodoimidazo[1,2-a]pyridine; 3-Iodo-7-trifluoromethylimidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine, 3-iodo-7-(trifluoromethyl)-; 1036990-96-1; AI3-32855; ZINC000103014756; AKOS025244023
EINECS	Contact for details

Quality Control

Our Imidazo[1,2-A]Pyridine, 3-Iodo-7-(Trifluoromethyl)- is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials. Due to its light-sensitive nature, handling should be performed under subdued lighting or using amber glass containers when appropriate.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.