Description

Azd-4547 CAS NO 1035270-39-3 is a potent and selective small molecule inhibitor targeting fibroblast growth factor receptor (FGFR) tyrosine kinases. This compound is of significant value for pharmaceutical research and development, particularly in the field of precision oncology. It is primarily needed by biotechnology companies, academic research institutions, and pharmaceutical developers focused on creating novel therapeutics for cancers driven by FGFR signaling dysregulation.

Application

• Biomedical Research: Used as a critical pharmacological tool to study FGFR signaling pathways and their role in cell proliferation, differentiation, and survival.
• Preclinical Drug Development: Serves as a reference compound or lead molecule in the discovery and optimization of new FGFR-targeted anticancer agents.
• Target Validation Studies: Employed in vitro and in vivo to validate FGFR as a therapeutic target in various cancer models, including bladder, breast, and lung cancers.
• Mechanism of Action (MoA) Analysis: Facilitates the understanding of drug resistance mechanisms and the exploration of combination therapy strategies.
• High-Throughput Screening (HTS): Can be utilized as a control or standard in screening assays designed to identify new FGFR inhibitors.
• Chemical Biology: Used in proteomics and chemoproteomics studies to map kinase inhibitor interactions and selectivity profiles.

Basic Information

Product Name	Azd-4547
CAS No.	1035270-39-3
Molecular Formula	C₂₁H₁₉FN₆O₂
Molecular Weight	406.41 g/mol
Synonyms	AZD-4547; AZD4547; 6-[2,6-Dichloro-3,5-dimethoxyphenyl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyridin-2-amine; 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-N-[(1S)-1,1,1-trifluoropropan-2-yl][1,2,4]triazolo[1,5-a]pyridin-2-amine; FGFR Inhibitor AZD4547
EINECS	Contact for details

Quality Control

Our Azd-4547 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and consistency for your research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.