Description

Rho-Kinase-In-1 is a potent and selective small molecule inhibitor of Rho-associated protein kinase (ROCK). This compound is a critical research tool for investigating the role of the Rho/ROCK signaling pathway in cellular processes such as cytoskeletal dynamics, cell motility, and smooth muscle contraction. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and basic biological research. Its high selectivity makes it invaluable for validating ROCK as a therapeutic target in various disease models.

Application

• Biochemical Research: Used as a selective inhibitor to study Rho-kinase (ROCK I/II) signaling pathways in vitro.
• Cell Biology Studies: Investigates the role of ROCK in actin cytoskeleton organization, cell adhesion, and migration.
• Neuroscience Research: Explores ROCK's function in neuronal growth cone collapse, axon guidance, and potential roles in neurological disorders.
• Cardiovascular Research: Studies the effects on vascular smooth muscle contraction, blood pressure regulation, and endothelial function.
• Oncology Research: Used in cancer research to examine ROCK's involvement in tumor cell invasion, metastasis, and angiogenesis.
• Drug Discovery & Screening: Serves as a reference standard and pharmacological tool in high-throughput screening (HTS) assays for identifying new ROCK inhibitors.

Basic Information

Product Name	Rho-Kinase-In-1
CAS No.	1035094-83-7
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	Rho-Kinase Inhibitor I; ROCK Inhibitor I; (S)-2-(2-(Dimethylamino)ethyl)-N-(5-((6-methoxy-1,5-naphthyridin-4-yl)amino)pyridin-2-yl)cyclopropanecarboxamide; Rho Kinase Inhibitor; RKI-1; CAS 1035094-83-7; ROCK Inhibitor (I)
EINECS	Contact for details

Quality Control

Our Rho-Kinase-In-1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment to guarantee reproducible and reliable research results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.