Description

n-[(1R,2R)-2-[(11Br)-3,5-Dihydro-4H-Dinaphth[2,1-C:1',2'-E]Azepin-4-Yl]-1,2-Diphenylethyl]-4-Methyl- Benzenesulfonamide is a high-purity, advanced pharmaceutical intermediate characterized by its complex chiral structure. This compound is critical for enabling sophisticated synthetic pathways in modern medicinal chemistry, particularly in the development of targeted therapeutics. It is primarily required by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of potential drug candidates, especially in oncology and central nervous system (CNS) research.
• Asymmetric Catalysis Research: Used as a ligand precursor or a model substrate in the development and study of new asymmetric catalytic reactions.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of complex organic molecules under Good Manufacturing Practice (GMP) conditions.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemists in both university laboratories and corporate R&D centers exploring new chemical entities.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	n-[(1R,2R)-2-[(11Br)-3,5-Dihydro-4H-Dinaphth[2,1-C:1',2'-E]Azepin-4-Yl]-1,2-Diphenylethyl]-4-Methyl- Benzenesulfonamide
CAS No.	1034835-91-0
Molecular Formula	C43H34BrN3O2S
Molecular Weight	736.72 g/mol
Synonyms	(1R,2R)-N-[2-(11-Bromo-3,5-dihydro-4H-dinaphtho[2,1-c:1',2'-e]azepin-4-yl)-1,2-diphenylethyl]-4-methylbenzenesulfonamide; 4-Methyl-N-[(1R,2R)-2-[(11-bromo-3,5-dihydro-4H-dinaphtho[2,1-c:1',2'-e]azepin-4-yl)-1,2-diphenylethyl]benzenesulfonamide; 1034835-91-0; (R,R)-Ts-DNBP-Br; Bromo-DNBP-Ts derivative; Chiral dinaphthazepine sulfonamide; Advanced chiral auxiliary.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Each lot is fully characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development under GMP-grade requirements for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.