Description

4-Bromo-2-(Trifluoromethyl)Pyrimidine is a high-value halogenated pyrimidine building block, distinguished by its bromine and trifluoromethyl substituents which impart unique reactivity and physicochemical properties. This compound is essential for medicinal chemistry and agrochemical research, enabling the rapid synthesis of novel molecules with enhanced biological activity and metabolic stability. It is primarily sought after by pharmaceutical R&D teams, agrochemical innovators, and advanced material scientists for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for functionalized organic materials, including liquid crystals and organic electronic components.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create diverse biaryl structures.
• Chemical Biology & Proteomics: Utilized as a versatile labeling agent or linker for probing biological systems and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethyl)Pyrimidine
CAS No.	1034827-56-9
Molecular Formula	C5H2BrF3N2
Molecular Weight	226.98 g/mol
Synonyms	4-Bromo-2-(trifluoromethyl)pyrimidine; 2-(Trifluoromethyl)-4-bromopyrimidine; 4-Bromo-2-trifluoromethylpyrimidine; Pyrimidine, 4-bromo-2-(trifluoromethyl)-; 1034827-56-9; 4-Bromo-2-(trifluoromethyl)-pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.