Description

P38α Inhibitor 1 is a potent and selective small molecule inhibitor of the p38α MAP kinase, a key signaling protein involved in cellular stress responses. This compound is critical for research and development in inflammatory and autoimmune disease pathways, offering a valuable tool for target validation and mechanistic studies. It is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel therapeutics for conditions like rheumatoid arthritis, COPD, and other inflammation-mediated diseases.

Application

• Biochemical Research: Used as a selective tool compound to study the role of p38α MAPK in cellular signaling cascades and stress response pathways.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in high-throughput screening and structure-activity relationship (SAR) studies for novel anti-inflammatory agents.
• In Vitro & In Vivo Studies: Applied in cell-based assays and preclinical animal models to investigate the efficacy and mechanism of p38α inhibition in disease models.
• Target Validation: Employed to confirm the therapeutic potential of p38α MAPK as a drug target in various autoimmune and chronic inflammatory disorders.
• Pharmaceutical Intermediates: Can be utilized in the synthesis of more complex drug candidates or analogs with optimized pharmacokinetic properties.

Basic Information

Product Name	P38α Inhibitor 1
CAS No.	1034189-82-6
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	P38α Inhibitor 1; BIRB 796; Doramapimod; 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea; N-[4-[2-(4-Morpholinyl)ethoxy]-1-naphthalenyl]-N'-[5-(1,1-dimethylethyl)-2-(4-methylphenyl)-3-pyrazolyl]urea; BIRB 0796; BIRB-0796; BIRB0796
EINECS	Contact for details

Quality Control

Our P38α Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee reproducibility and traceability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be sealed under dry conditions and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.