Description

Licofelone Acyl--D-Glucuronide is a key metabolite and reference standard of the dual COX/LOX inhibitor licofelone, a compound of significant pharmaceutical research interest. This glucuronide conjugate is essential for pharmacokinetic and metabolic stability studies, providing critical insights into drug disposition and clearance pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on anti-inflammatory drug development and analytical method validation.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of licofelone and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, bioavailability, and excretion profile of licofelone.
• Analytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, and LC-MS/MS methods for bioanalytical assays.
• Preclinical and Clinical Research: Supports toxicology studies and clinical trial sample analysis to ensure accurate metabolite profiling.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring comprehensive metabolite identification and characterization.
• Biochemical Research: Employed in studies exploring the role of glucuronidation in modulating drug activity and toxicity.

Basic Information

Product Name	Licofelone Acyl--D-Glucuronide
CAS No.	1033702-58-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Licofelone Glucuronide; Licofelone Acyl Glucuronide; 2-[2,2-Dimethyl-6-(4-chlorobenzoyl)-1,2-dihydro-3H-pyrrolo[3,2,1-ij]quinolin-1-yl]-1-(β-D-glucopyranuronosyl)-1H-pyrrole-5-carboxylic acid; Licofelone Metabolite; ML-3000 Glucuronide; (2R,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[2-[2,2-dimethyl-6-(4-chlorobenzoyl)-1,2-dihydro-3H-pyrrolo[3,2,1-ij]quinolin-1-yl]-5-carboxypyrrol-1-yl]oxane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Licofelone Acyl--D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.