Description

[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]Methanol is a high-value pyridine derivative and versatile chemical building block, essential for advanced synthesis in pharmaceutical and agrochemical research. Its core value lies in the strategic combination of a reactive chloropyridine scaffold with a hydroxymethyl functional group, enabling precise molecular construction. This compound is critically needed by R&D chemists and process development scientists for creating novel active ingredients, particularly in the development of crop protection agents and pharmaceutical intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Active Ingredient Precursor: Serves as a critical building block in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced bioactivity.
• Ligand Synthesis for Catalysis: Used in the preparation of specialized pyridine-based ligands for transition metal catalysis in fine chemical production.
• Material Science Research: Employed in the development of functionalized polymers and advanced organic materials with specific electronic properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes and scale-up projects.

Basic Information

Product Name	[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]Methanol
CAS No.	1033463-31-8
Molecular Formula	C7H5ClF3NO
Molecular Weight	211.57 g/mol
Synonyms	(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methanol; 2-Pyridinemethanol, 3-chloro-5-(trifluoromethyl)-; 3-Chloro-5-trifluoromethyl-2-pyridinemethanol; 2-(Hydroxymethyl)-3-chloro-5-(trifluoromethyl)pyridine; 3-Chloro-5-(trifluoromethyl)picolinyl alcohol
EINECS	Contact for details

Quality Control

Every batch of [3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]Methanol is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical intermediate grade meets stringent internal specifications, with testing typically including HPLC for assay and impurity profiling, NMR and IR for structural confirmation, and Karl Fischer titration for water content. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. This material should be stored separately from strong bases and fluorinating agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.