Description

2-Bromo-5-Chloro-4-Fluoropyridine is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its precise halogen substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, including herbicides and fungicides, where its halogenated structure contributes to biological activity.
• Material Science Research: Employed as a precursor for the synthesis of functionalized ligands, organic electronic materials, and liquid crystals.
• Cross-Coupling Reactions: Serves as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to introduce the pyridine core into more complex architectures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.

Basic Information

Product Name	2-Bromo-5-Chloro-4-Fluoropyridine
CAS No.	1033203-45-0
Molecular Formula	C5H2BrClFN
Molecular Weight	210.43 g/mol
Synonyms	5-Chloro-2-bromo-4-fluoropyridine; 4-Fluoro-2-bromo-5-chloropyridine; 2-Bromo-5-chloro-4-fluoropyridine; Pyridine, 2-bromo-5-chloro-4-fluoro-; 1033203-45-0
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Chloro-4-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.