Description

Mk-2206 2Hcl CAS NO 1032350-13-2 is a potent, selective, and ATP-competitive allosteric inhibitor of the Akt (Protein Kinase B) signaling pathway. This compound is a critical research tool for studying cellular processes related to cell survival, proliferation, and metabolism. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology, metabolic disease, and signal transduction research.

Application

• Biochemical Research: A key reagent for in vitro studies to elucidate the role of Akt isoforms in various cellular pathways.
• Pharmaceutical Development: Used as a reference standard and pharmacological tool in the discovery and validation of novel cancer therapeutics targeting the PI3K/Akt/mTOR axis.
• Cell Biology Studies: Employed to inhibit Akt activity in cell culture models to investigate its function in apoptosis, glucose metabolism, and cell growth.
• Preclinical Research: Utilized in animal models to study the therapeutic potential of Akt inhibition for treating tumors and other proliferative diseases.

Basic Information

Product Name	Mk-2206 2Hcl
CAS No.	1032350-13-2
Molecular Formula	C28H41N7O3 · 2HCl
Molecular Weight	604.6 g/mol (as free base: 523.67 g/mol)
Synonyms	MK-2206 dihydrochloride; Akt Inhibitor MK-2206 2HCl; 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride; MK2206 2HCl; MK 2206 dihydrochloride
EINECS	Contact for details

Quality Control

Our Mk-2206 2Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.