Description

Ralimetinib is a potent and selective small-molecule inhibitor targeting the p38 MAPK (mitogen-activated protein kinase) signaling pathway, specifically the alpha isoform. This compound is of significant interest in pharmaceutical research and development due to its potential role in modulating inflammatory responses and cellular stress. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology, immunology, and inflammatory disease research. Ralimetinib CAS NO 1029939-86-3 represents a critical tool compound for investigating novel therapeutic strategies.

Application

• Biochemical Research: Used as a selective inhibitor to study the p38 MAPK signaling pathway's role in cellular processes.
• Drug Discovery & Development: Serves as a key reference standard and lead compound in oncology and anti-inflammatory drug development programs.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate efficacy in cancer and inflammatory disease models.
• Mechanism of Action (MoA) Studies: Essential for elucidating the biological functions and therapeutic potential of p38α inhibition.
• High-Throughput Screening (HTS): Used as a control or tool compound in screening assays to identify new drug candidates.
• Academic Research: Facilitates fundamental research in molecular biology, cell signaling, and disease mechanisms at universities and institutes.

Basic Information

Product Name	Ralimetinib
CAS No.	1029939-86-3
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	LY2228820; Ralimetinib (LY2228820); 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-pyridinyl]-N-[(3R)-3-fluoropyrrolidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide; 1H-Pyrazolo[3,4-b]pyridine-4-carboxamide, 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-pyridinyl]-N-[(3R)-3-fluoropyrrolidin-1-yl]-; p38 MAPK inhibitor LY2228820; LY 2228820
EINECS	Contact for details

Quality Control

Our Ralimetinib is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided, documenting key parameters to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.