Description

3-Fluoropyridine-4-Boronic Acid Hydrate is a high-purity organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated pyridine cores in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with fluorinated heterocyclic structures.
• Material Science Research: Serves as a building block for creating organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and biochemical tools due to the versatility of the boronic acid functional group.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and heterobiaryl linkages.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry.

Basic Information

Product Name	3-Fluoropyridine-4-Boronic Acid Hydrate
CAS No.	1029880-18-9
Molecular Formula	C5H6BFNO2 • xH2O
Molecular Weight	140.92 (Anhydrous basis)
Synonyms	(3-Fluoropyridin-4-yl)boronic acid hydrate; 3-Fluoro-4-pyridineboronic acid hydrate; 4-Borono-3-fluoropyridine hydrate; 3-Fluoro-4-pyridylboronic acid; 3-Fluoro-4-pyridinylboronic acid; 3-Fluoropyridine-4-boronic acid; 3-Fluoro-4-(dihydroxyboryl)pyridine hydrate
EINECS	Contact for details

Quality Control

Our 3-Fluoropyridine-4-Boronic Acid Hydrate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Anhydrous basis)
Water Content (KF)	≤10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.