Description

n-(4-Ethynylphenyl)-6,7-Bis(2-Methoxyethoxy)Quinazolin-4-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of targeted cancer therapeutics, particularly tyrosine kinase inhibitors. It is primarily required by pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical producers engaged in the development of novel oncology drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potent and selective tyrosine kinase inhibitors (TKIs) for oncology research and drug development.
• Anticancer Drug Candidate Synthesis: Used in the construction of novel small-molecule drug candidates targeting specific cancer pathways, such as EGFR (Epidermal Growth Factor Receptor) inhibitors.
• Biochemical Research: Serves as a tool compound or a reference standard in biochemical assays to study enzyme inhibition and cellular signaling mechanisms.
• Preclinical Development: Employed in the scale-up and process optimization stages for new chemical entities (NCEs) before clinical trials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for the custom synthesis of complex molecules for client-specific projects.

Basic Information

Product Name	n-(4-Ethynylphenyl)-6,7-Bis(2-Methoxyethoxy)Quinazolin-4-Amine
CAS No.	1029721-32-1
Molecular Formula	C21H21N3O4
Molecular Weight	379.41 g/mol
Synonyms	6,7-Bis(2-methoxyethoxy)-N-(4-ethynylphenyl)quinazolin-4-amine; 4-[(4-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline; EGFR Inhibitor Intermediate; Afatinib Impurity/Intermediate; BIBW 2992 Intermediate; TKI Building Block; Quinazoline Derivative CAS 1029721-32-1
EINECS	Contact for details

Quality Control

Our n-(4-Ethynylphenyl)-6,7-Bis(2-Methoxyethoxy)Quinazolin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.