Description

2-(Difluoromethyl)-6-Methylpyridine is a specialized fluorinated pyridine derivative, a key building block in advanced organic synthesis. Its unique difluoromethyl group adjacent to the pyridine nitrogen makes it a valuable intermediate for introducing fluorine atoms into target molecules, a critical step in modulating the physicochemical and biological properties of final compounds. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, CNS agents, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl moiety can improve compound activity and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating novel nitrogen-containing ligands used in transition metal catalysis for asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals or electronic chemicals, where fluorination tunes electronic properties.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research focused on exploring new methodologies for C-F bond formation and the study of fluorinated heterocycles.

Basic Information

Product Name	2-(Difluoromethyl)-6-Methylpyridine
CAS No.	1029691-30-2
Molecular Formula	C7H7F2N
Molecular Weight	143.13 g/mol
Synonyms	6-Methyl-2-(difluoromethyl)pyridine; 2-(Difluoromethyl)-6-picoline; 2,6-Lutidine, 2-(difluoromethyl)-; 6-Methyl-2-difluoromethylpyridine; 2-Difluoromethyl-6-methylpyridine; Pyridine, 2-(difluoromethyl)-6-methyl-; 1029691-30-2 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethyl)-6-Methylpyridine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our standard quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.