Description

n-[5-(Trifluoromethyl)Pyridin-2-Yl]Valine is a high-value, non-proteinogenic amino acid derivative featuring a trifluoromethylpyridine moiety. This compound is a critical building block in modern pharmaceutical and agrochemical research, offering unique physicochemical properties that enhance the metabolic stability and bioavailability of target molecules. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Research: Used in constructing advanced active ingredients for crop protection products, leveraging the trifluoromethyl group for improved efficacy.
• Chemical Biology Probe Synthesis: Serves as a modified amino acid for creating peptide mimetics and activity-based probes to study enzyme function.
• Material Science: Potential monomer or additive for specialty polymers where fluorine incorporation is desired for specific surface properties.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects and scale-up development.

Basic Information

Product Name	n-[5-(Trifluoromethyl)Pyridin-2-Yl]Valine
CAS No.	1028251-32-2
Molecular Formula	C12H13F3N2O2
Molecular Weight	274.24 g/mol
Synonyms	2-((5-(Trifluoromethyl)pyridin-2-yl)amino)-3-methylbutanoic acid; Valine, N-[5-(trifluoromethyl)-2-pyridinyl]-; (2S)-2-[[5-(Trifluoromethyl)pyridin-2-yl]amino]-3-methylbutanoic acid; (S)-2-((5-(Trifluoromethyl)pyridin-2-yl)amino)-3-methylbutanoic acid; N-(5-Trifluoromethyl-2-pyridinyl)valine; 1028251-32-2; UNII-9J8K4A9V6S
EINECS	Contact for details

Quality Control

Every batch of n-[5-(Trifluoromethyl)Pyridin-2-Yl]Valine is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.