Description

1-Bromo-2-(2,2-Difluoroethyl)-Benzene is a high-value, halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex molecules, particularly those requiring the introduction of a difluoroethyl moiety adjacent to a reactive bromine handle. Pharmaceutical, agrochemical, and material science R&D teams need it to create novel active ingredients and functional materials, leveraging its unique reactivity profile for coupling reactions and further functionalization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing fluorinated ethylbenzene scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the difluoroethyl group can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Development: Serves as a building block for fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying the effects of gem-difluoro substitution on the physical and chemical properties of organic compounds.
• Polymer & Specialty Chemical Modification: Used to introduce fluorinated aromatic units into polymer backbones or specialty chemicals to alter solubility, thermal stability, or surface properties.

Basic Information

Product Name	1-Bromo-2-(2,2-Difluoroethyl)-Benzene
CAS No.	1027513-80-9
Molecular Formula	C8H7BrF2
Molecular Weight	221.04 g/mol
Synonyms	2-(2,2-Difluoroethyl)bromobenzene; o-(2,2-Difluoroethyl)bromobenzene; 1-Bromo-2-(2,2-difluoroethyl)benzene; Benzene, 1-bromo-2-(2,2-difluoroethyl)-; (2-Bromophenyl)(2,2-difluoro)ethane; 2-Bromo-1-(2,2-difluoroethyl)benzene; α,α-Difluoro-2-bromophenethyl
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(2,2-Difluoroethyl)-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.