Description

3-Hydroxy Fenretinide is a synthetic retinoid derivative and a key metabolite of the investigational drug Fenretinide. This compound matters for its role in advanced pharmaceutical research, particularly in the study of apoptosis and cell differentiation pathways. It is primarily needed by research institutions and pharmaceutical developers focused on oncology, dermatology, and metabolic disease therapeutics. The product is supplied as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate for preclinical and analytical applications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in QC laboratories.
• Oncology Research: Serves as a critical biochemical tool for studying retinoid-mediated apoptosis and anti-cancer mechanisms in various cell lines.
• Metabolite Studies: Essential for pharmacokinetic and metabolic profiling studies of Fenretinide in drug discovery and development.
• API Intermediate: Employed in the synthesis and scale-up of novel retinoid-based therapeutic candidates.
• Biochemical Assays: Used in high-throughput screening (HTS) and in vitro assays to evaluate biological activity and receptor binding.
• Dermatological Research: Applied in research exploring the modulation of skin cell proliferation and differentiation.

Basic Information

Product Name	3-Hydroxy Fenretinide
CAS No.	1027233-22-2
Molecular Formula	C26H33NO3
Molecular Weight	407.55 g/mol
Synonyms	N-(4-Hydroxyphenyl)retinamide; 4-HPR metabolite; Fenretinide Metabolite; 3-Hydroxy-4-HPR; (2E,4E,6E,8E)-3-Hydroxy-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide; 3-OH-Fenretinide; 3-Hydroxyretinoid; 3-Hydroxy Fenretinide
EINECS	Contact for details

Quality Control

Our 3-Hydroxy Fenretinide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure compliance with ICH guidelines and customer-specific requirements. A comprehensive Certificate of Analysis (COA) detailing all test results and methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature of 15-25°C to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.