Description

Tie-2 And Aurora Inhibitor 1 is a potent, small-molecule dual inhibitor targeting the Tie-2 receptor tyrosine kinase and Aurora kinase family, key regulators of angiogenesis and cell cycle progression. This compound is a critical research tool for investigating tumor biology, vascular development, and signaling pathways in oncology and cardiovascular disease models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in preclinical drug discovery and mechanistic studies. The high specificity and activity of this inhibitor make it an essential component for developing novel therapeutic strategies.

Application

• Oncology Research: Investigation of tumor angiogenesis, metastasis, and cell proliferation pathways in various cancer cell lines and xenograft models.
• Kinase Profiling & Selectivity Studies: Used as a reference compound in high-throughput screening and biochemical assays to study kinase inhibition profiles.
• Vascular Biology Research: Study of endothelial cell function, vascular permeability, and pathological angiogenesis in cardiovascular and inflammatory diseases.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore model for the design and synthesis of next-generation kinase inhibitors.
• Mechanistic & Pathway Analysis: Elucidation of the crosstalk between the Tie-2 and Aurora kinase signaling networks in cellular models.
• Apoptosis & Cell Cycle Research: Analysis of mitotic defects and induction of programmed cell death in rapidly dividing cells.

Basic Information

Product Name	Tie-2 And Aurora Inhibitor 1
CAS No.	1025751-71-6
Molecular Formula	C₂₃H₂₀N₆O₂
Molecular Weight	412.45 g/mol
Synonyms	TAI-1; Tie2/Aurora Inhibitor 1; 6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one; CCT241736; Aurora Kinase/TIE2 Inhibitor; VEGFR-2/TIE-2/Aurora Inhibitor; Dual TIE-2 and Aurora Kinase Inhibitor
EINECS	Contact for details

Quality Control

Every batch of Tie-2 And Aurora Inhibitor 1 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and potency. Our standard grade meets high-purity research specifications, with Certificates of Analysis (COA) provided for each lot, detailing results from HPLC, NMR, and mass spectrometry. We support research compliance with traceable documentation and can accommodate custom purity requirements for specific applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.