Description

6-Fluoropyridine-3-Sulfonyl Chloride is a high-purity, reactive organofluorine building block essential for advanced chemical synthesis. This compound matters as a versatile sulfonylation reagent, enabling the precise introduction of the 6-fluoro-3-pyridylsulfonyl moiety into target molecules. It is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require the fluoropyridine sulfonyl pharmacophore.
• Material Science Research: Serves as a precursor for functionalized ligands, monomers, or surface-modifying agents in advanced polymers and coatings.
• Chemical Biology & Proteomics: Employed as a reactive handle for activity-based protein profiling (ABPP) or the creation of covalent enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	6-Fluoropyridine-3-Sulfonyl Chloride
CAS No.	1025509-80-1
Molecular Formula	C5H3ClFNO2S
Molecular Weight	195.60 g/mol
Synonyms	3-Pyridinesulfonyl chloride, 6-fluoro-; 6-Fluoro-3-pyridinesulfonyl chloride; 6-Fluoropyridine-3-sulfonyl chloride; 2-Fluoropyridine-5-sulfonyl chloride; 5-Sulfonylchloride-2-fluoropyridine
EINECS	Contact for details

Quality Control

Our 6-Fluoropyridine-3-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.