Description

Rac Cinacalcet Hcl CAS NO 1025064-33-8 is a high-purity chemical reference standard and research material, specifically the racemic form of the calcimimetic agent Cinacalcet. This compound is of significant value for pharmaceutical research and development, particularly in studies related to calcium metabolism and parathyroid hormone (PTH) regulation. It serves as a critical analytical standard for method development, quality control, and comparative studies in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Used as a primary standard in HPLC, LC-MS, and other analytical methods for the quantification and qualification of Cinacalcet and its related substances.
• Research & Development: Essential for preclinical and pharmacological research investigating calcium-sensing receptor (CaSR) agonists and their mechanisms of action.
• Process Chemistry & Impurity Profiling: Employed in the development and validation of synthetic routes for Cinacalcet HCl, aiding in the identification and control of process-related impurities and enantiomers.
• Academic Studies: Utilized in university and institutional labs for biochemical and medicinal chemistry research focused on endocrine disorders.
• Method Development: Serves as a key component in developing and calibrating chiral separation methods for pharmaceutical analysis.

Basic Information

Product Name	Rac Cinacalcet Hcl
CAS No.	1025064-33-8
Molecular Formula	C22H23ClF3N • HCl
Molecular Weight	434.34 g/mol (for free base C22H23ClF3N)
Synonyms	Racemic Cinacalcet Hydrochloride; (±)-N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine Hydrochloride; Cinacalcet Racemate HCl; (R,S)-Cinacalcet HCl; NPS R-568 Racemate Hydrochloride; UNII-1K860WSG25 (racemate); (Rac)-Cinacalcet HCl
EINECS	Contact for details

Quality Control

Our Rac Cinacalcet Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, IR and MS for identification, and rigorous control of residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all test results against stringent in-house specifications developed for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Racemic mixture (approx. 50:50 ratio)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.