Description

Arl 67156 is a high-purity, small molecule chemical compound used as a potent and selective inhibitor of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1). This compound matters for researchers and developers as it serves as a critical tool for studying purinergic signaling pathways, bone mineralization disorders, and related physiological processes. It is needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on metabolic diseases, oncology, and inflammation.

Application

• Pharmaceutical Research & Development: A key biochemical tool for investigating the role of NPP1 in various disease models, including cancer metastasis and calcific diseases.
• Enzymology Studies: Used as a selective inhibitor to elucidate the function and mechanism of NPP1 in in vitro and cellular assays.
• Metabolic Disorder Research: Applied in studies targeting disorders of ectopic calcification, such as pseudoxanthoma elasticum (PXE) and arterial calcification.
• Academic & Preclinical Studies: Serves as a reference standard and active compound in university and institutional labs for signal transduction research.
• Biotech Screening Platforms: Utilized in high-throughput screening (HTS) campaigns to identify novel therapeutics targeting nucleotide metabolism.
• Inflammation and Immunology Research: Investigated for its potential modulatory effects on purinergic signaling in immune cells.

Basic Information

Product Name	Arl 67156
CAS No.	1021868-83-6
Molecular Formula	C₁₇H₁₅N₅O₃
Molecular Weight	337.34 g/mol
Synonyms	ARL 67156; ARL-67156; 6-N,N-Diethyl-β,γ-dibromomethylene-D-adenosine-5'-triphosphate; 6-N,N-Diethyl-β,γ-dibromomethylene-D-ATP; Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase 1 Inhibitor; NPP1 Inhibitor; Ecto-ATPase Inhibitor
EINECS	Contact for details

Quality Control

Our Arl 67156 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation, NMR and MS for structural identity, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.