Description

Dodecanoyl-L-Carnitine-[D3] Hydrochloride (Solution) is a high-purity, isotopically labeled internal standard essential for precise quantitative analysis in mass spectrometry. This compound is critical for ensuring accuracy and reliability in metabolic and pharmacokinetic studies by correcting for instrument variability and sample preparation losses. It is primarily needed by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions conducting advanced bioanalytical and metabolomics research.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the accurate LC-MS/MS quantification of endogenous L-carnitine and its esters in biological matrices like plasma, serum, and urine.
• Metabolomics Research: Used in stable isotope dilution assays to profile and quantify acylcarnitines, providing insights into metabolic pathways and disorders such as fatty acid oxidation defects.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug-induced changes in carnitine homeostasis and fatty acid metabolism during preclinical and clinical trials.
• Diagnostic Assay Development: Employed in the calibration and validation of high-throughput clinical diagnostic tests for inborn errors of metabolism.
• Nutritional and Sports Science: Facilitates the study of carnitine supplementation and its impact on energy metabolism and athletic performance.
• Drug Metabolism Studies: Acts as a tracer to investigate the metabolic fate of carnitine-related compounds and potential drug candidates.

Basic Information

Product Name	Dodecanoyl-L-Carnitine-[D3] Hydrochloride (Solution)
CAS No.	1021439-26-8
Molecular Formula	C19H35D3ClNO4
Molecular Weight	~378.97 g/mol
Synonyms	Lauroyl-L-carnitine-d3 hydrochloride; Dodecanoyl-L-carnitine-d3 HCl; (3R)-3-[(1-Oxododecyl-d3)oxy]-4-(trimethylammonio)butanoate hydrochloride; L-Carnitine dodecanoate-d3 ester hydrochloride; C12:0 Carnitine-d3 hydrochloride; Deuterated Lauroylcarnitine HCl; Isotope-labeled acylcarnitine standard
EINECS	Contact for details

Quality Control

Our Dodecanoyl-L-Carnitine-[D3] Hydrochloride (Solution) is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D3), chemical purity by HPLC, and solution concentration. We adhere to relevant GMP and ISO guidelines for the production of reference materials.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the solution at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to slightly yellow
Identification (HPLC/MS)	Conforms to reference standard
Isotopic Enrichment (D3)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 95%
Concentration	Typically 0.1-1.0 mg/mL in methanol or acetonitrile
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.