Description

4-Bromo-2-(Chloromethyl)-1-Fluorobenzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring bromine, chlorine, and fluorine substituents on a benzene ring, makes it a critical precursor for constructing complex molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries. It serves as a key intermediate for the development of active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the halogen atoms provide specific bioactivity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and organometallic catalysts.
• Material Science Research: Employed in the synthesis of monomers and functionalized aromatics for advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful for introducing halogen tags into molecules for use in imaging, proteomics, and other bioconjugation applications.

Basic Information

Product Name	4-Bromo-2-(Chloromethyl)-1-Fluorobenzene
CAS No.	1020992-68-0
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-Bromo-4-(chloromethyl)-3-fluorobenzene; 2-(Chloromethyl)-4-bromo-1-fluorobenzene; 4-Bromo-2-(chloromethyl)fluorobenzene; 3-Fluoro-4-bromobenzyl chloride; Benzene, 4-bromo-2-(chloromethyl)-1-fluoro-; (4-Bromo-3-fluorophenyl)methyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-(Chloromethyl)-1-Fluorobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including results from HPLC, GC, NMR, and other relevant analytical techniques, is supplied with each shipment to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.