Description

Rac Tenofovir-D6 CAS NO 1020719-94-1 is a deuterated isotopologue of the antiviral drug tenofovir, serving as a critical internal standard for quantitative mass spectrometry analysis. This high-purity reference material is essential for ensuring the accuracy and reliability of analytical methods in pharmaceutical research and quality control. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in the development, bioanalysis, and regulatory compliance of antiviral therapeutics.

Application

• Internal Standard for LC-MS/MS: Used as a stable, isotopically labeled internal standard for the precise quantification of tenofovir and its prodrugs in biological matrices (plasma, serum, tissues).
• Pharmaceutical R&D: Supports method development and validation in pharmacokinetic (PK), pharmacodynamic (PD), and bioequivalence studies for antiviral drugs.
• Metabolite Tracing: Facilitates metabolic stability studies and the identification of drug metabolites in preclinical and clinical research.
• Quality Control & Assurance: Employed in the quality control testing of active pharmaceutical ingredients (APIs) and finished drug products to ensure potency and purity.
• Forensic and Doping Analysis: Acts as a reference compound in forensic toxicology and anti-doping control for the detection of tenofovir-related substances.

Basic Information

Product Name	Rac Tenofovir-D6
CAS No.	1020719-94-1
Molecular Formula	C9H8D6N5O4P
Molecular Weight	291.22 g/mol (deuterated form)
Synonyms	Tenofovir-d6; PMPA-d6; (R)-9-(2-Phosphonylmethoxypropyl)adenine-d6; (R)-PMPA-d6; GS 1278-d6; (Rac)-Tenofovir-d6; Deuterated Tenofovir; 9-[(R)-2-[[Bis[[(2,2,2-trideuterioethoxy)hydroxyphosphinyl]]methoxy]propyl]adenine
EINECS	Contact for details

Quality Control

Our Rac Tenofovir-D6 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity, NMR and MS for structural confirmation, and determination of isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the exact specifications and test results to ensure the material meets the stringent requirements for analytical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.