Description

n-Methylguanidine-D3 is a stable isotope-labeled analog of n-methylguanidine, where three hydrogen atoms are replaced by deuterium. This compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reproducibility in analytical measurements. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, agrochemical, and life science sectors for method development, pharmacokinetic studies, and metabolite identification.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of n-methylguanidine and related metabolites in complex biological matrices like plasma, urine, and tissue samples.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• Clinical Diagnostics: Enables accurate measurement of biomarker levels in patient samples for research into renal function and related metabolic disorders.
• Metabolomics and Proteomics: Serves as a stable isotope tracer in metabolic pathway analysis and protein modification studies.
• Agrochemical Analysis: Applied in the environmental fate and residue analysis of pesticides and herbicides that degrade into or interact with guanidine compounds.
• Chemical Reference Material: Provides a certified reference material for calibrating analytical instruments and validating testing methods in compliance with GLP and ISO 17025 standards.

Basic Information

Product Name	n-Methylguanidine-D3
CAS No.	1020719-65-6
Molecular Formula	C₂H₂D₃N₃
Molecular Weight	77.10 g/mol
Synonyms	N-Methylguanidine-d3; (Methyl-d3)guanidine; Guanidine, N-methyl-d3; 1-Methylguanidine-d3; Deuterated N-Methylguanidine; Methylguanidine (N-methyl-d3); N-(Methyl-d3)guanidine; Stable Isotope Labeled N-Methylguanidine
EINECS	Contact for details

Quality Control

Our n-Methylguanidine-D3 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant standards for high-purity reference materials to support your research and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.