Description

5-Hydroxymethyl-n-Phenyl-2-1H-Pyridone-D5 is a deuterated isotopologue of a hydroxymethyl-substituted pyridone derivative, serving as a critical stable isotope-labeled standard. This compound is essential for ensuring accuracy and reliability in quantitative analytical methods, particularly in pharmaceutical and biomedical research. It is primarily required by research institutions, analytical laboratories, and pharmaceutical companies engaged in method development, pharmacokinetic studies, and metabolic profiling.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of its non-deuterated counterpart.
• Metabolic Pathway Tracing: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track and quantify metabolites.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredients (APIs).
• Bioanalytical Method Validation: Critical for validating analytical methods according to ICH, FDA, and EMA guidelines, ensuring specificity and accuracy.
• Stable Isotope Dilution Assay (SIDA): Provides high-precision quantification in complex biological matrices like plasma, serum, and tissue homogenates.
• Research Chemical Synthesis: Acts as a labeled building block for synthesizing more complex deuterated molecules for research purposes.

Basic Information

Product Name	5-Hydroxymethyl-n-Phenyl-2-1H-Pyridone-D5
CAS No.	1020719-52-1
Molecular Formula	C₁₂H₆D₅NO₂
Molecular Weight	~216.24 g/mol
Synonyms	5-(Hydroxymethyl)-1-phenyl-2(1H)-pyridinone-d5; 1-Phenyl-5-(hydroxymethyl)-2(1H)-pyridinone-d5; 5-Hydroxymethyl-1-phenyl-2-pyridone-d5; Deuterated 5-Hydroxymethyl Phenyl Pyridone; [D5]-5-Hydroxymethyl-1-phenyl-2(1H)-pyridone; 5-Hydroxymethyl-1-phenyl-1H-pyridin-2-one-d5; 1020719-52-1; 5-HM-PP-D5
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure high isotopic purity and chemical purity, critical for their role as analytical standards. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and other relevant specifications to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.