Description

2-Hydroxy-1-Methyl-6-Phenylimidazo(4,5-B)Pyridine-D3 is a deuterated analog of a heterocyclic aromatic amine, specifically designed for use as a high-purity analytical standard and stable isotope-labeled internal standard. This compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry and other advanced analytical techniques. It is primarily needed by research institutions, pharmaceutical development laboratories, and contract research organizations (CROs) engaged in metabolism studies, pharmacokinetic research, and method validation.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard for the precise quantification of its non-deuterated counterpart in complex biological matrices.
• Metabolite Identification & Pharmacokinetics: Essential in drug metabolism and pharmacokinetic (DMPK) studies to track and quantify parent compounds and metabolites.
• Analytical Method Development & Validation: Serves as a critical reference material for developing, calibrating, and validating sensitive HPLC and mass spectrometry methods.
• Food Safety & Environmental Analysis: Applied in the detection and quantification of heterocyclic aromatic amines (HAAs) in food products and environmental samples.
• Toxicological Research: Used in studies investigating the formation, exposure, and biological impact of cooked food mutagens.
• Certified Reference Material (CRM): A candidate for the production of certified reference materials to ensure data integrity across laboratories.

Basic Information

Product Name	2-Hydroxy-1-Methyl-6-Phenylimidazo(4,5-B)Pyridine-D3
CAS No.	1020719-48-5
Molecular Formula	C13H8D3N3O
Molecular Weight	228.27 g/mol
Synonyms	2-Hydroxy-1-Methyl-6-Phenylimidazo[4,5-b]pyridine-d3; 2-Hydroxy-1,6-Dimethylimidazo[4,5-b]pyridine-d3 (Phenyl-d3); 2-OH-1-Me-6-PhIP-d3; Deuterated 2-Hydroxy-PhIP; [D3]-2-Hydroxy-1-Methyl-6-Phenylimidazo(4,5-B)Pyridine; Stable Isotope Labeled HAA Standard; PhIP Metabolite-d3; Imidazopyridine-d3 Derivative
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-1-Methyl-6-Phenylimidazo(4,5-B)Pyridine-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and chromatographic data are provided with each shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.