Description

n-Acetylsulfathiazole-D4 is a high-purity, deuterium-labeled internal standard critical for precise quantitative analysis in modern analytical laboratories. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, particularly when analyzing its non-labeled counterpart. It is primarily utilized by pharmaceutical research and development teams, contract research organizations (CROs), and analytical testing laboratories engaged in method development, pharmacokinetic studies, and quality control.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial reference compound for the accurate quantification of sulfathiazole and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track drug distribution, bioavailability, and clearance rates with high precision.
• Veterinary Drug Residue Analysis: Enables reliable monitoring and detection of sulfonamide antibiotic residues in food-producing animals to ensure food safety compliance.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and bioanalytical method validation for clinical trials involving sulfonamide-class therapeutics.
• Environmental Testing: Facilitates the trace analysis of pharmaceutical pollutants in environmental water samples using advanced hyphenated techniques.
• Method Development & Validation: Provides a stable isotopic diluent to correct for matrix effects and instrument variability, improving assay robustness and reproducibility.

Basic Information

Product Name	n-Acetylsulfathiazole-D4
CAS No.	1020718-91-5
Molecular Formula	C11H7D4N3O3S2
Molecular Weight	285.36 g/mol
Synonyms	4-Acetamido-N-(2-thiazolyl)benzenesulfonamide-d4; N1-(2-Thiazolyl)sulfanilamide-d4 Acetate; Sulfathiazole-d4 N-Acetate; Deuterated N-Acetylsulfathiazole; [D4]-N-Acetylsulfathiazole; 2-(p-Acetamidobenzenesulfonamido)thiazole-d4; 4-Acetamidobenzenesulfonothiazolide-d4
EINECS	Contact for details

Quality Control

Every batch of n-Acetylsulfathathiazole-D4 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and mass spectrometry to confirm deuteration level and structural identity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and solvent residue data to support your regulatory submissions and internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration Degree)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.