Description

Tie-2 Inhibitor 7 is a potent and selective small molecule inhibitor of the Tie-2 (TEK) receptor tyrosine kinase. This compound matters for researchers and developers as it provides a critical tool for modulating angiogenesis and lymphangiogenesis pathways in preclinical studies. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, ophthalmology, and inflammatory disease research.

Application

• Angiogenesis Research: Used as a key pharmacological tool to study the role of the Tie-2 signaling pathway in blood vessel formation and stability.
• Oncology Drug Discovery: Employed in target validation and compound screening for anti-cancer therapies aimed at disrupting tumor vasculature.
• Lymphangiogenesis Studies: Applied in research investigating lymphatic system development and related pathological conditions.
• Ocular Disease Models: Utilized in preclinical research for retinal and choroidal neovascularization disorders, such as age-related macular degeneration (AMD).
• Inflammatory Condition Research: Investigated for its potential role in modulating inflammation where Tie-2 signaling is implicated.
• Biochemical Assay Development: Serves as a reference standard in developing high-throughput screening (HTS) and kinase profiling assays.

Basic Information

Product Name	Tie-2 Inhibitor 7
CAS No.	1020412-97-8
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	N-[4-(2-Amino-4-pyrimidinyl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea; Tie-2 Kinase Inhibitor; Tie2 Inhibitor; 1-(4-(2-Aminopyrimidin-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea; CAS 1020412-97-8; Tie-2 Receptor Inhibitor; Tie-2/ANG-2 Inhibitor
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Each batch is characterized to confirm identity, purity, and stability. Certificates of Analysis (COA) are available upon request, providing detailed results from analytical methods including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.