Description

6-Chloro-5-Fluoropyridine-3-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its unique halogenated pyridine structure, which serves as a versatile scaffold for constructing complex molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated pyridine core.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing properties.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Chemical Biology & Proteomics: Used to create molecular probes and tags for studying biological systems and protein function.

Basic Information

Item	Details
Product Name	6-Chloro-5-Fluoropyridine-3-Carbonitrile
CAS No.	1020253-14-8
Molecular Formula	C6H2ClFN2
Molecular Weight	156.54 g/mol
Synonyms	5-Fluoro-6-chloropyridine-3-carbonitrile; 3-Cyano-5-fluoro-6-chloropyridine; 6-Chloro-5-fluoro-3-pyridinecarbonitrile; 6-Chloro-5-fluoronicotinonitrile; 2-Chloro-3-fluoro-5-cyanopyridine; 1020253-14-8; 6-Chloro-5-fluoropyridin-3-yl cyanide
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Fluoropyridine-3-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, supporting our clients' regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.