Description

Mono-6-o-(2-Naphthyl)-Per-o-Methyl-α-Cyclodextrin is a chemically modified α-cyclodextrin derivative featuring a single 2-naphthyl group attached via a methylated spacer at the 6-position of the glucose unit. This molecular design is critical for creating highly specific host-guest complexes, significantly enhancing the solubility, stability, and bioavailability of hydrophobic target molecules. It is an essential advanced material for researchers and formulators in pharmaceutical development, analytical chemistry, and specialty chemical synthesis who require precise molecular encapsulation and chiral separation capabilities.

Application

• Pharmaceutical Research & Drug Delivery: As a solubility enhancer and stabilizer for poorly water-soluble active pharmaceutical ingredients (APIs) in pre-formulation studies.
• Chiral Separation & Analysis: Serving as a chiral selector or stationary phase modifier in High-Performance Liquid Chromatography (HPLC) and Capillary Electrophoresis (CE) for enantiomeric resolution.
• Catalysis & Organic Synthesis: Acting as a supramolecular catalyst or nano-reactor to control reaction selectivity and regiochemistry in synthetic chemistry.
• Sensor Development: Utilized in the construction of fluorescent or electrochemical sensors, where the naphthyl group acts as a signaling moiety upon guest inclusion.
• Food & Flavor Technology: For the encapsulation and controlled release of sensitive flavors, fragrances, or nutraceuticals to mask bitterness or prevent degradation.
• Material Science: As a building block for creating functionalized polymers, gels, or surfaces with specific molecular recognition properties.

Basic Information

Product Name	Mono-6-o-(2-Naphthyl)-Per-o-Methyl-α-Cyclodextrin
CAS No.	1019999-18-8
Molecular Formula	C58H84O30
Molecular Weight	1237.26 g/mol
Synonyms	6A-O-(2-Naphthyl)-Per-O-methyl-α-Cyclodextrin; Heptakis(2,3,6-tri-O-methyl)-6A-O-(2-naphthyl)-α-cyclodextrin; Mono-6-deoxy-6-(2-naphthylthio)-per-O-methyl-α-cyclodextrin (related precursor); 2-Naphthyl-permethylated-α-CD derivative; Naphthyl-functionalized permethyl α-cyclodextrin; 6I-O-(2-Naphthyl)-heptakis(2,3,6-tri-O-methyl)-α-cyclodextrin; Mono-substituted naphthyl permethyl α-CD
EINECS	Contact for details

Quality Control

Our Mono-6-o-(2-Naphthyl)-Per-o-Methyl-α-Cyclodextrin is produced under strict quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency suitable for research and development applications. Comprehensive analysis includes HPLC for purity and substitution degree, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Substitution Degree (NMR)	0.9 - 1.1 (Mono-substituted)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in common organic solvents (e.g., DMSO, Chloroform)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.